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Microplastic toxicity : A review of the role of marine sentinel species inassessing the environmental and public health impacts

The ubiquity of plastics is a concern for the health of humans and marine ecosystems. Plastics and their composite endocrine disrupting chemicals (EDCs) are associated with adverse health outcomes in humans and marine species. With continued plastic production, waste mismanagement and global population increases, exposure effects will continue to escalate...

Induced Torpor as a Countermeasure for Low Dose Radiation Exposure in a Zebrafish Model

The development of the Artemis programme with the goal of returning to the moon is spurring technology advances that will eventually take humans to Mars and herald a new era of interplanetary space travel. However, long-term space travel poses unique challenges including exposure to ionising radiation from galactic cosmic rays ...

Microplastics in the marine environmen - A review of their sources, distribution processes, uptake and exchange in ecosystems

The ubiquity of plastics is a concern for the health of humans and marine ecosystems. Plastics and their compositeendocrine disrupting chemicals (EDCs) are associated with adverse health outcomes in humans and marinespecies. With continued plastic production, waste mismanagement and global population increases, exposureeffects will continue to escalate...

Human cardiac organoids for the modelling of myocardial infarction and drug cardiotoxicity

Environmental factors are the largest contributors to cardiovascular disease. Here we show that cardiac organoids that incor- porate an oxygen-diffusion gradient and that are stimulated with the neurotransmitter noradrenaline model the structure of the human heart after myocardial infarction (by mimicking the infarcted, border and remote zones), and recapitulate hallmarks of...

Nutritional challenges and countermeasures for space travel

There has been a reinvigoration of public interest in space exploration in what has been deemed the new space race, which aims to eventually take humans to Mars in the 2030s. This type of Earth‐independent deep space mission presents a multitude of challenges for...

The effects of rosiglitazone on the neonatal rat cardiomyocyte transcriptome: a temporal analysis

The objective was to determine via high-throughput RNA sequencing the temporal effects of rosiglitazone (Avandia®) on the neonatal rat ventricular myocyte transcriptome. Materials & methods: Neonatal rat ventricular myocytes (NRVMs) were exposed to rosiglitazone in vitro. Meta analyses utilized temporal comparisons of 0.5 h control versus 0.5 h treatment, 0.5 h treatment versus...

Meta-analysis Of Dolphin And Human Peripheral Blood Mononuclear Cells Reveals Inflammatory Signatures Associated With Exposure To High Levels Of Perfluoroalkyl Substances

Currently a fundamental gap exists on how persistent organic pollutants affect humans especially those who consume high levels of seafood from contaminated coastal waters. There is an urgent need to better understand effects of these contaminants on human health in coastal communities. Elevated contaminant levels in coastal seafood will give rise to...

miRmapper: A Tool for Interpretation of miRNA⁻mRNA Interaction Networks

It is estimated that 30% of all genes in the mammalian cells are regulated by microRNA (miRNAs). The most relevant miRNAs in a cellular context are not necessarily those with the greatest change in expression levels between healthy and diseased tissue. Differentially expressed (DE) miRNAs that modulate a large number of messenger RNA (mRNA) transcripts ultimately have a greater...

Systems Analysis of the Liver Transcriptome in Adult Male Zebrafish Exposed to the Plasticizer (2-Ethylhexyl) Phthalate (DEHP)

The organic compound diethylhexyl phthalate (DEHP) represents a high production volume chemical found in cosmetics, personal care products, laundry detergents, and household items. DEHP, along with other phthalates causes endocrine disruption in males. Exposure to endocrine disrupting chemicals has been linked to the development of several adverse health outcomes with apical end points including Non-Alcoholic Fatty Liver Disease (NAFLD). This...